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KMID : 0370219980420010089
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Yakhak Hoeji
1998 Volume.42 No. 1 p.89 ~ p.94
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Screening of the Antibacterial Activity of Natural Products aganist Propionibacterium acnes
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최승만/Choi SM
김민주/최영호/안호정/윤여표/Kim MJ/Choi YH/Ahn HJ/Yun YP
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Abstract
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Propionibacterium acnes is the pharmacological target site of antiacne drugs. We have examined the antiacne activity of ninety seven natural products which have been used as Korean traditional medicines in various skin disorders. The antibacterial activity of extracts from the natural products were evaluated against P. acnes ATCC 9616 by disc method. Twelve natural products showed the potent antibacterial activity against P. acnes, and were, selected for the minimal inhibitory concentration(MC) against P. acnes. MICs of nine extracts were below 0.3% (w/v) and Sophora flavescens showed the most potent activity with a MIC of less than 0.008%(w/v) against P. acnes. Thus, the results suggest that nine natural products including S. flavescens can be developed as sources of promising potent antiacne agents.
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